Fig. 2

Pharmacoeconomic model structure. Response was defined as a ≥50 % reduction from baseline in the number of CH attacks during the randomised period (or during month 2 in the case of 4 late responders). Responders in the SoC group were modelled as non-responders beyond the randomised phase. Probability of response was modelled for the base case (response maintained) and for the following alternative scenarios: 1) constant rate of response loss, 2) diminishing rate of response loss, and 3) no initial response in the SoC group. Abbreviations: CH cluster headache; SoC standard of care