Altered effective connectivity of posterior thalamus in migraine with cutaneous allodynia: a resting-state fMRI study with granger causality analysis

Table 4 Two sample t-test (voxel-level P < 0.01 and cluster-level P < 0.05 Gaussian random field corrected) of difference for causal influence to and from the right posterior thalamus

Regions	Peak voxel MNI coordinates (mm)			T value	Total voxels	Breakdown (number of voxels)
Regions	x	y	z	T value	Total voxels	Breakdown (number of voxels)
MWCA vs. HC
Causal outflow from R posterior thalamus to the rest of brain (X to Y)
R Cerebrum//Inferior Parietal Lobule//Temporal_Sup_R	58	−30	22	−4.146	473	SupraMarginal_R (346)
						Parietal_Inf_R (63)
						Temporal_Sup_R (52)
						Angular_R (12)
L Cerebrum//Supramarginal Gyrus//Parietal_Inf_L	−60	−46	38	−3.852	198	SupraMarginal_L (156)
						Parietal_Inf_L (27)
						Temporal_Sup_L (15)
Causal inflow to R posterior thalamus from the rest of brain (Y to X)
R Cerebrum//Middle Temporal Gyrus//Temporal_Sup_R	60	−6	−8	4.509	281	Frontal_Inf_Oper_R (154)
						Temporal_Sup_R (69)
						Temporal_Pole_Sup_R (40)
						Rolandic_Oper_R (18)
R Cerebrum//Frontal_Mid_R	46	38	20	5.0173	490	Frontal_Mid_R (265)
						Frontal_Inf_Tri_R (155)
						Frontal_Mid_Orb_R (59)
						Frontal_Inf_Orb_R (11)
L Cerebrum//Temporal_Sup_L	−56	−32	10	4.1279	318	SupraMarginal_L (172)
						Temporal_Sup_L (65)
						Parietal_Inf_L (45)
						Postcentral_L (36)
R Cerebrum//Inferior Parietal Lobule//SupraMarginal_R	60	−30	38	3.9594	216	SupraMarginal_R (191)
						Parietal_Inf_R (25)
MWCA vs. MWoCA
Causal inflow to R posterior thalamus from the rest of brain (Y to X)
R Cerebrum//Anterior Cingulate//Olfactory_R	6	18	−4	4.3433	148	Caudate_R (101)
						Olfactory_R (47)

HC healthy control, L left, MNI Montreal Neurological Institute, MWCA migraineurs with cutaneous allodynia, MWoCA migraineurs without cutaneous allodynia; R right

ISSN: 1129-2377