Altered effective connectivity of posterior thalamus in migraine with cutaneous allodynia: a resting-state fMRI study with granger causality analysis

Table 3 Two sample t-test (voxel-level P < 0.01 and cluster-level P < 0.05 Gaussian random field corrected) of difference for causal influence to and from the left posterior thalamus

Regions	Peak voxel MNI coordinates (mm)			T value	Total voxels	Breakdown (number of voxels)
Regions	x	y	z	T value	Total voxels	Breakdown (number of voxels)
MWCA vs. HC
Causal outflow from L posterior thalamus to the rest of brain (X to Y)
L Cerebrum//Medial Frontal Gyrus//Rectus_L	−10	34	−20	4.2681	257	Rectus_L (137)
						Frontal_Sup_Orb_L (68)
						Frontal_Med_Orb_L (52)
R Cerebrum//Medial Frontal Gyrus	20	48	14	4.8552	242	Frontal_Sup_Medial_R (86)
						Frontal_Sup_Medial_L (71)
						Frontal_Sup_R (54)
						Cingulum_Ant_R (31)
Causal inflow to L posterior thalamus from the rest of brain (Y to X)
L Cerebrum//Occipital Lobe//Precuneus//Cuneus_L	−14	−62	28	−4.7685	404	Precuneus_L (189)
						Precuneus_R (127)
						Cuneus_L (45)
						Cingulum_Post_L (43)
MWCA vs. MWoCA
Causal inflow to L posterior thalamus from the rest of brain (Y to X)
L Cerebrum//Parahippocampa Gyrus//Amygdala_L	−24	−4	−18	−3.7253	163	Amygdala_L (65)
						Hippocampus_L (53)
						Putamen_L (28)
						Pallidum_L (17)
L Cerebrum//Cingulate Gyrus//Frontal_Sup_Medial_L	−4	20	40	−4.8582	162	Frontal_Sup_Medial_L (65)
						Supp_Motor_Area_L (50)
						Cingulum_Mid_L (35)
						Cingulum_Mid_R (12)

HC healthy control, L left, MNI Montreal Neurological Institute, MWCA migraineurs with cutaneous allodynia, MWoCA migraineurs without cutaneous allodynia, R right

ISSN: 1129-2377