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Table 3 Allele frequencies of gene polymorphism in Chinese population

From: Case-control study of GRIA1 and GRIA3 gene variants in migraine

Gene

SNP

Group

Allele n(%)

P

GRIA1

rs548294

 

G

A

 

Migraine

448(67.7)

214(32.3)

.752

MA

72(76.6)

22(23.4)

.110

MO

376(66.2)

192(33.8)

.394

Control

452(68.5)

208(31.5)

 

rs2195450

 

C

T

 

Migraine

557(84.1)

105(15.9)

.001*

MA

77(81.9)

17(18.1)

.012**

MO

480(84.5)

88(15.5)

.002***

Control

597(90.5)

63(9.5)

 

GRIA3

rs3761555

 

G

A

 

Migraine

424(64.0)

238(36.0)

.579

MA

61(64.9)

33(35.1)

.663

MO

363(63.9)

205(36.1)

.629

Control

413(62.5)

247(37.4)

 
  1. Abbreviations: MA migraine with aura, MO migraine without aura, SNP single nucleotide polymorphisms, CI confidence interval
  2. *All female migraine patients compared with controls by allele: odds ratio =1.786, 95 % CI: 1.28–2.49, P < .017
  3. **MA compared with controls by allele: odds ratio =2.092, 95 % CI: 1.17–3.76, P < .017
  4. ***MO compared with controls by allele: odds ratio =1.737, 95 % CI: 1.23–2.45, P < .017