Inclusion criteria | Exclusion criteria |
• Chronic refractory headache disorder according to ICHD-3 beta criteria • Age ≥18 years • Migraine attacks that are refractory to medical or behavioural therapy • Eligible for nVNS therapy • Willingness to comply with a defined follow-up interval • Intracranial and cervical pathologies ruled out by an MRI scan • Stable pain medication for 4 weeks prior to nVNS | • Other concomitant neuropsychiatric comorbidity that is not adequately classified or requires a specific diagnosis or treatment • Pregnancy • Previous invasive or non-invasive neuromodulation therapy or ablative procedure • Unwillingness to complete pain diary and provide information on pain intensity and migraine attack frequency (i.e. number of migraine attacks per month) • Cerebrovascular or cardiovascular disease |