Fig. 5

NF-κB staining of trigeminal ganglia from control (fresh), inflammatory (2 or 10 days post-CFA) and treated (KYNA and KYNAA2) groups. a In fresh trigeminal ganglia, NF-κB immunoreactive neuronal nuclei (thin arrow) were found. b-c At 2 and 10 days post-CFA injection, all of the neurons showed increased NF-κB intensity (thick arrow), out of them a few small- and medium-sized neurons seemed to be positive (thin arrowhead). Some of the neuronal nuclei showed higher NF-κB-expression (thin arrow). d-e KYNAA2- and KYNA-treatment at 2 days did not alter the expression of NF-κB; thick arrow points at intense neuronal NF-κB expression, some of these immunoreactive neurons were identified as small- to medium sized neurons (arrow head), thin arrow points at immunoreactive neuronal nuclei. f After 10 days KYNA-treatment, the staining was similar to the staining of the healthy group