Fig. 3
From: Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion
pERK1/2 immunohistochemistry of trigeminal ganglia from control (fresh), inflammatory (2 or 10 days post-CFA) and treated (KYNA and KYNAA2) groups. a In fresh trigeminal ganglia, pERK1/2 positive nuclei with nucleoli (thin arrows) and only nucleoli (thin arrow heads) were seen. b-c At 2 and 10 days post-CFA injection, pERK1/2-immunoreactive SGCs (thick arrows) were present. In addition, at 10 days post-CFA injection, some positive nuclei and nucleoli were also found (thin arrow). d-e KYNA and KYNAA2 abolished the pERK1/2-positivity in the SGCs (thick arrowheads) at 2 days. f After 10 days KYNA-treatment, both negative SGCs (thick arrowhead) and positive SGCs (thick arrow) were seen. Insert scale bars 50 μm