Fig. 10

At 2 days post-CFA injection in the trigeminal ganglion the pERK1/2 immunoreactive SGCs induce the activation of NF-κB in the small- and medium sized neurons, which co-localize with CGRP. Presumably, the activation of NF-κB promotes the release of CGRP from small- and medium sized neurons. The released CGRP displays its effect on SGCs and large neurons, which contain the CGRP receptor components, the CLR and RAMP1 in the trigeminal ganglion