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Table 1 Literature prevalence of migraine in patients with epilepsy

From: Headache in epilepsy: prevalence and clinical features

Authors

Sample

M/F

Age

Methods

Results

N of pts

yrs

Migraine

Schon and Blau 1987 [5]

100

39/61

32 mean

Interview

9 %

Ottman and Lipton 1994 [6]

1948

40 %/60 %

≥18

Structured telephone interviews + medical records review for 60 % of probands

24 %

Ito and Shachter 1996 [7]

162

82/80

19-65 range

Questionnaires mailed to the subjects + medical records review

NAa

Ito et al. 1999 [8]

109

36/73

38 ± 12 meanb

Questionnaire + interview + medical records review

12.8 %

Velioglu and Ozmenoglu 1999[9]

412

212/200

15-70 range

Interview with a standardized questionnaire

14 %

Leniger et al. 2001 [10]

341

154/187

40 ± 15 mean

Interview with a standardized questionnaire

18.2 %

Karaali Savrun et al. 2002 [11]

135

80/55

≥10

Questionnaire administered to patients

14.8 %

Förderreuther et al. 2002 [12]

110

69/41

35.2 mean

Semi-standardized interview

10 %b

Ito et al. 2004 [13]

364

163/201

12-81 range

Structured interview with standardized questionnaire

8 %

Syvertsen et al. 2007 [14]

109

44/65

20-71 range

Questionnaire + semi-structured telephonic interview

20 %

Kwan et al. 2008 [15]

227

98/129

36.0 ± 11.3 mean

Interview with standardized questionnaire + seizures and headache diary over the 3-month observation period + final interview

6.6 %b

HELP Study Group 2010 [16]

597

348/249

≥13

Questionnaire at initial visit

12.4 %

Tonini et al. 2012 [17]

492c

154/338

≥18

Direct interview with questionnaire

18.3 %b

Duchaczek et al. 2012 [18]

201

106/95

≥18

Semi-structured interview

11 %

Winawer et al. 2013 [19]

730d

285/445

≥12

Telephone or in-person interview + medical record abstraction

25.2 %e

Gameleira et al. 2013 [20]

304

141/163

4-88 range

Patients evaluated at the epilepsy clinic

32.9 %f

Wang et al. 2014 [21]

1109

607/502

≥18

Self-administered questionnaire + standardized semi-structured telephone interview

12.53 %

  1. N, number; pts, patients; M, males; F, females; yrs, years; NA, not available
  2. aa prevalence of inter-ictal migraine is not clearly identifiable; the authors report a prevalence of inter-ictal headache in 64 % of patients, approximately a half of them with a pounding quality and almost 70 % of them often accompanied by nausea and/or vomiting, photophobia or phonophobia
  3. bcalculated by the authors
  4. cthis multicenter study involved 1167 patients from epilepsy and headache centers, we considered only patients with epilepsy
  5. d371 probands, 231 siblings, 128 parents: all with epilepsy; e23.5 % probands, 22.5 % siblings, 35.2 % parents
  6. fthe authors of the study does not distinguish between inter-ictal migraine and post-ictal headache with migrainous features