Validation of the Patient Health Questionnaire-9 (PHQ-9) and PHQ-2 in patients with migraine

Table 3 ROC analyses of the PHQ-9 and PHQ-2 for the diagnosis of current MDD as determined by the MINI-Plus 5.0.0

Cut off score	Sensitivity	Specificity	PPV	NPV	AUC	SE	95 % CI	p value
PHQ-9
>5	87.2	67.3	53.1	92.6	0.775	0.043	0.690–0.859	<0.001
>6	82.1	75.3	58.2	90.9	0.787	0.044	0.700–0.873	<0.001
>7	79.5	81.7	64.6	90.5	0.806	0.044	0.720–0.892	<0.001
>8	71.8	87.1	70.0	88.0	0.794	0.047	0.702–0.887	<0.001
>9	64.1	90.3	73.5	85.7	0.772	0.050	0.674–0.870	<0.001
PHQ-2
>1	89.7	63.4	50.7	93.7	0.766	0.043	0.682–0.850	<0.001
>2	66.7	90.3	74.3	86.6	0.785	0.049	0.689–0.881	<0.001
>3	48.7	97.8	90.5	82.0	0.733	0.054	0.626–0.839	<0.001

ROC Receiver operating characteristic, PHQ-9 Patient Health Questionnaire-9, PHQ-2 Patient Health Questionnaire-2, MDD Major Depressive Disorder, MINI-Plus 5.0.0 Mini International Neuropsychiatric Interview-Plus Version 5.0.0, PPV positive predictive value, NPV negative predictive value, AUC area under the curve

ISSN: 1129-2377