Table 2 Results of primary and secondary treatment outcome measures
| Â | Intention-t-treat analysis | Per protocol analysis | ||||
|---|---|---|---|---|---|---|
|  | 1 Hz (n = 22) | 25 Hz (n = 24) | Group comparison | 1 Hz (n = 17) | 25 Hz (n = 22) | Group comparison |
Change in headache days/28 days | −5.6 ± 5.0 | −3.0 ± 5.3 | F[42] = 2.94 | −7.0 ± 4.6 | −3.3 ± 5.4 | F[35] = 4.82 |
(−5.9; −0.5) | (−8.5; −3.2) | p = 0.094 | (−9.6; −4.1) | (−5.9; −0.4) | p  = 0.035 | |
Responder (50 % reduction in headache days) | 5 (22.7 %) | 3 (12.5 %) | OR = 2.44 | 5 (29.4 %) | 3 (13.6 %) | OR = 3.21 |
p = 0.29 | p = 0.18 | |||||
Change in headache intensity (NRS 0 – 10) | −0.1 ± 1.1 (n = 20) | 0.2 ± 1.0 | F[40] = 0.30 | 0.02 ± 1.2 (n = 15) | 0.2 ± 1.0 | F[33] = 0.28 |
(−0.2; 0.9) | (−0.4; 0.7) | p = 0.58 | (−0.4; 0.8) | (−0.2; 0.9) | p = 0.60 | |
Change in days with acute headache medication in 28 days | −2.0 ± 4.2 | −1.3 ± 4.4 | F[42] = 0.01 | −2.7 ± 4.5 | −1.6 ± 4.1 | F[35] < 0.01 |
(−4.2; −0.3) | (−4.4; −0.3) | p = 0.91 | (−4.7; −0.4) | (−4.7; −0.3) | p = 0.96 | |
Change in MIDAS score | −18.7 ± 28.0 | −21.8 ± 54.5 | F[42] < 0.01 | −24.2 ± 29.8 | −26.5 ± 53.9 | F[35] < 0.01 |
(−38.6; −0.9) | (−39.2; −0.8) | p = 0.98 | (−43.2; −4.0) | (−42.1; −3.7) | p = 0.96 | |
Change in HIT-6 score | −2.5 ± 6.8 | −3.8 ± 5.5 | F[42] = 0.12 | −3.8 ± 7.1 | −3.9 ± 5.69 | F[35] = 0.01 |
(−6.7; −0.7) | (−7.3; −1.2) | p = 0.73 | (−7.8; −1.1) | (−7.6; −1.0) | p = 0.93 | |