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Table 2 Changes in migraine, frequency, intensity and use of pain medication during use of the contraceptive pill desogestrel 75 μg over 180 days of use

From: Positive effects of the progestin desogestrel 75 μg on migraine frequency and use of acute medication are sustained over a treatment period of 180 days

Days/month

Mean baseline (SD)

Mean treatment TP 1(SD)

Mean treatment TP 2 (SD)

Overall P-value

P-value baseline vs. TP 1

Posthoc* P-value baseline vs. TP2

P-value TP 1 vs TP 2

Headache days

4.1 (4.5)

3.8 (4.1)

3.0 (4.1)

0.051

0.867

0.050

0.062

Migraine days

5.8 (4.3)

3.7 (3.4)

3.6 (4.0)

<0.001

<0.001

0.001

0.701

Sum headache and migraine

9.4 (5.1)

7.6 (5.5)

6.6 (5.4)

0.002

0.008

<0.001

0.130

Headache intensity

15.7 (7.6)

11.4 (7.5)

10.7 (8.0)

<0.001

<0.001

<0.001

0.312

Days with headache score 3 in 3 months

5.4 (4.2)

2.2 (2.7)

2.4 (3.5)

<0.001

<0.001

<0.001

0.776

Pain medication

7.2 (5.9)

5.0 (3.3)

5.0 (4.0)

0.044

<0.001

0.015

0.751

Triptan use in 3 months

12.3 (15.0)

8.1 (9.4)

7.8 (10.2)

0.035

0.010

0.041

0.599

  1. Baseline: 90 days before treatment; TP = treatment period. TP1: Treatment period days 1–90; TP2: Treatment period days 91–180.
  2. *after Bonferroni correction, post-hoc p-values are significant at p < 0.017.