Skip to main content

Advertisement

Table 2 Clinical Outcomes and Quality of Life means (SD) at 0 months (baseline), 3 months and 6 months in Idiopathic intracranial hypertension

From: Headache determines quality of life in idiopathic intracranial hypertension

  0 months (baseline) 3 months 6 months   
  Mean (SD) Mean (SD) Mean (SD) P-value Effect size
Clinical outcomes      
Weight (kg) 101.5 (16.0) 102.5 (16.8) 86.8 (15.6) <0.001 0.92
BMI 38.2 (5.0) 38.6 (5.3) 32.6 (4.7) <0.001 1.12
Intracranial pressure (cm H2O) 39.8 (5.1) 38.0 (5.0) 30.0 (4.9) <0.001 1.92
Headache disability (HIT-6) 57.5 (9.0) 54.5 (1.0) 46.9 (10.1) 0.004 1.18
Headache severity (VAS) 3.8 (2.4) 4.2 (2.8) 1.9 (2.8) 0.015 0.79
Headache frequency (days/week) 3.8 (2.9) 4.4 (2.9) 2.1 (2.8) 0.011 0.59
Papilloedema (OCT) 144.1 (45.5) 135.0 (48.0) 109.3 (27.9) 0.001 0.76
Visual acuity (LogMar) -0.02 (0.10) 0.01 (0.11) -0.06 (0.09) <0.001 0.40
Analgesic use (days/week) 2.2 (2.7) 2.2 (2.5) 0.2 (0.4) 0.007 0.74
Quality of life (SF-36)      
Physical functioning 77.3 (22.9) 79.8 (21.2) 87.6 (19.4) <0.001 -0.45
Role limitation due to physical problems 70.6 (29.3) 78.1 (24.7) 91.4 (16.9) <0.001 -0.71
Role limitation due to emotional problems 78.8 (30.0) 76.0 (28.8) 90.1 (18.7) 0.018 -0.38
Social functioning 66.7 (30.3) 78.1 (19.6) 86.9 (22.8) 0.081 -0.67
Mental health 63.2 (22.4) 67.2 (20.5) 74.6 (21.3) 0.048 -0.51
Energy/Vitality 39.4 (20.8) 49.6 (14.4) 71.0 (23.4) <0.001 -1.52
Pain 53.2 (20.2) 67.6 (26.8) 85.2 (16.2) 0.001 -1.58
General health perception 53.1 (18.8) 53.7 (18.6) 72.1 (12.7) 0.001 -1.01
Change in health 52.1 (19.4) 60.4 (19.4) 88.1 (17.0) <0.001 -1.86
Physical component score 40.4 (10.3) 44.1 (10.5) 50.7 (7.4) <0.001 -1.00
Mental component score 45.2 (12.7) 47.1 (9.8) 52.(10.4) 0.020 -0.54
Number 24 24 20   
  1. HIT-6, Six-item Headache Impact Test; OCT, Optical Coherence Tomography. VAS, Visual Analogue Score; LogMar, Logarithm of the Minimum Angle of Resolution. The quality of life scale ranges from 0 (worst quality of life) to 100 (best quality of life). There were no significant differences between 0 and 3 months (no diet), except for pain (p=0.025) and energy/vitality (p=0.020). P values in the table indicate changes from 3 to 6 months (following diet). If a Bonferroni correction were applied the p value is reduced to p < 0.0026, but this might represent an overcorrection. Effect size (ES) in the final column indicates the magnitude of change: ES=0.30 indicates mild/low change, ES=0.50 indicates moderate change and ES ≥ 0.80 indicates large change.