From: Headache determines quality of life in idiopathic intracranial hypertension
0 months (baseline) | 3 months | 6 months | |||
---|---|---|---|---|---|
Mean (SD) | Mean (SD) | Mean (SD) | P-value | Effect size | |
Clinical outcomes | |||||
Weight (kg) | 101.5 (16.0) | 102.5 (16.8) | 86.8 (15.6) | <0.001 | 0.92 |
BMI | 38.2 (5.0) | 38.6 (5.3) | 32.6 (4.7) | <0.001 | 1.12 |
Intracranial pressure (cm H2O) | 39.8 (5.1) | 38.0 (5.0) | 30.0 (4.9) | <0.001 | 1.92 |
Headache disability (HIT-6) | 57.5 (9.0) | 54.5 (1.0) | 46.9 (10.1) | 0.004 | 1.18 |
Headache severity (VAS) | 3.8 (2.4) | 4.2 (2.8) | 1.9 (2.8) | 0.015 | 0.79 |
Headache frequency (days/week) | 3.8 (2.9) | 4.4 (2.9) | 2.1 (2.8) | 0.011 | 0.59 |
Papilloedema (OCT) | 144.1 (45.5) | 135.0 (48.0) | 109.3 (27.9) | 0.001 | 0.76 |
Visual acuity (LogMar) | -0.02 (0.10) | 0.01 (0.11) | -0.06 (0.09) | <0.001 | 0.40 |
Analgesic use (days/week) | 2.2 (2.7) | 2.2 (2.5) | 0.2 (0.4) | 0.007 | 0.74 |
Quality of life (SF-36) | |||||
Physical functioning | 77.3 (22.9) | 79.8 (21.2) | 87.6 (19.4) | <0.001 | -0.45 |
Role limitation due to physical problems | 70.6 (29.3) | 78.1 (24.7) | 91.4 (16.9) | <0.001 | -0.71 |
Role limitation due to emotional problems | 78.8 (30.0) | 76.0 (28.8) | 90.1 (18.7) | 0.018 | -0.38 |
Social functioning | 66.7 (30.3) | 78.1 (19.6) | 86.9 (22.8) | 0.081 | -0.67 |
Mental health | 63.2 (22.4) | 67.2 (20.5) | 74.6 (21.3) | 0.048 | -0.51 |
Energy/Vitality | 39.4 (20.8) | 49.6 (14.4) | 71.0 (23.4) | <0.001 | -1.52 |
Pain | 53.2 (20.2) | 67.6 (26.8) | 85.2 (16.2) | 0.001 | -1.58 |
General health perception | 53.1 (18.8) | 53.7 (18.6) | 72.1 (12.7) | 0.001 | -1.01 |
Change in health | 52.1 (19.4) | 60.4 (19.4) | 88.1 (17.0) | <0.001 | -1.86 |
Physical component score | 40.4 (10.3) | 44.1 (10.5) | 50.7 (7.4) | <0.001 | -1.00 |
Mental component score | 45.2 (12.7) | 47.1 (9.8) | 52.(10.4) | 0.020 | -0.54 |
Number | 24 | 24 | 20 |