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Table 2 Clinical Outcomes and Quality of Life means (SD) at 0 months (baseline), 3 months and 6 months in Idiopathic intracranial hypertension

From: Headache determines quality of life in idiopathic intracranial hypertension

 

0 months (baseline)

3 months

6 months

  
 

Mean (SD)

Mean (SD)

Mean (SD)

P-value

Effect size

Clinical outcomes

     

Weight (kg)

101.5 (16.0)

102.5 (16.8)

86.8 (15.6)

<0.001

0.92

BMI

38.2 (5.0)

38.6 (5.3)

32.6 (4.7)

<0.001

1.12

Intracranial pressure (cm H2O)

39.8 (5.1)

38.0 (5.0)

30.0 (4.9)

<0.001

1.92

Headache disability (HIT-6)

57.5 (9.0)

54.5 (1.0)

46.9 (10.1)

0.004

1.18

Headache severity (VAS)

3.8 (2.4)

4.2 (2.8)

1.9 (2.8)

0.015

0.79

Headache frequency (days/week)

3.8 (2.9)

4.4 (2.9)

2.1 (2.8)

0.011

0.59

Papilloedema (OCT)

144.1 (45.5)

135.0 (48.0)

109.3 (27.9)

0.001

0.76

Visual acuity (LogMar)

-0.02 (0.10)

0.01 (0.11)

-0.06 (0.09)

<0.001

0.40

Analgesic use (days/week)

2.2 (2.7)

2.2 (2.5)

0.2 (0.4)

0.007

0.74

Quality of life (SF-36)

     

Physical functioning

77.3 (22.9)

79.8 (21.2)

87.6 (19.4)

<0.001

-0.45

Role limitation due to physical problems

70.6 (29.3)

78.1 (24.7)

91.4 (16.9)

<0.001

-0.71

Role limitation due to emotional problems

78.8 (30.0)

76.0 (28.8)

90.1 (18.7)

0.018

-0.38

Social functioning

66.7 (30.3)

78.1 (19.6)

86.9 (22.8)

0.081

-0.67

Mental health

63.2 (22.4)

67.2 (20.5)

74.6 (21.3)

0.048

-0.51

Energy/Vitality

39.4 (20.8)

49.6 (14.4)

71.0 (23.4)

<0.001

-1.52

Pain

53.2 (20.2)

67.6 (26.8)

85.2 (16.2)

0.001

-1.58

General health perception

53.1 (18.8)

53.7 (18.6)

72.1 (12.7)

0.001

-1.01

Change in health

52.1 (19.4)

60.4 (19.4)

88.1 (17.0)

<0.001

-1.86

Physical component score

40.4 (10.3)

44.1 (10.5)

50.7 (7.4)

<0.001

-1.00

Mental component score

45.2 (12.7)

47.1 (9.8)

52.(10.4)

0.020

-0.54

Number

24

24

20

  
  1. HIT-6, Six-item Headache Impact Test; OCT, Optical Coherence Tomography. VAS, Visual Analogue Score; LogMar, Logarithm of the Minimum Angle of Resolution. The quality of life scale ranges from 0 (worst quality of life) to 100 (best quality of life). There were no significant differences between 0 and 3 months (no diet), except for pain (p=0.025) and energy/vitality (p=0.020). P values in the table indicate changes from 3 to 6 months (following diet). If a Bonferroni correction were applied the p value is reduced to p < 0.0026, but this might represent an overcorrection. Effect size (ES) in the final column indicates the magnitude of change: ES=0.30 indicates mild/low change, ES=0.50 indicates moderate change and ES ≥ 0.80 indicates large change.