Table 2 Distributions of genotype and allele frequencies of COMT polymorphism rs4680 and rs4818 observed in patients and controls
| Â | N | rs4680 genotypes ( % ) | rs4680 alleles (%) | HW (P value) | |||
|---|---|---|---|---|---|---|---|
| Â | Â | AA (Met/Met) | AG (Met/Val) | GG (Val/Val) | A | G | Â |
Controls | 132 | 23 (17.4) | 65 (49.2) | 44 (33.3) | 111 (42.0) | 153 (58.0) | 0,90 |
All patients with migraine | 380 | 78 (20.5) | 192 (50.5) | 110 (28.9) | 348 (45.7) | 412 (54.3) | 0,73 |
Migraine with Aura | 65 | 15 (23.1) | 30 (46.1) | 20 (30.8) | 60 (46.2) | 70 (53.8) | 0,56 |
Migraine w/out Aura | 189 | 41 (21.7) | 96 (50.8) | 52 (27.5) | 178 (47.1) | 200 (52.9) | 0,79 |
Chronic Migraine | 126 | 22 (17.5) | 66 (52.4) | 38 (30.1) | 110 (43.7) | 142 (56.3) | 0,47 |
| Â | N | rs4818 genotypes ( % ) | rs4818 alleles ( % ) | HW (P value) | |||
| Â | Â | CC (Leu/Leu) | CG (Leu/Leu) | GG (Leu/Leu) | C | G | Â |
Controls | 132 | 30 (22.7) | 76 (57.6) | 26 (19.7) | 136 (51.5) | 128 (48.5) | 0,08 |
All patients with migraine | 380 | 111 (29.3) | 197 (51.8) | 72 (18.9) | 419 (55.1) | 341 (44.9) | 0,35 |
Migraine with Aura | 65 | 21 (32.3) | 30 (46.2) | 14 (21.5 ) | 72 (55.4) | 58 (44.6) | 0,59 |
Migraine w/out Aura | 189 | 50 (26.5) | 104 (55.0) | 35 (18.5) | 204 (54.0) | 174 (46.0) | 0,14 |
Chronic Migraine | 126 | 40 (31,7) | 63 (50.0) | 23 (18.3) | 143 (56.7) | 109 (43.3) | 0,84 |