Patients (M/F) | Headache subtype | Healthy controls (M/F) | Mean age (years) | Country, Race-Ethnicity | Polymorphism | Comment | Reference |
---|---|---|---|---|---|---|---|
62 (11/51) | -Migraine with aura (33) | 64 (14/50) | -Patients (32 ± 5.2) | Turkey, Asian | rs4680 | Association between the Met allele and migraine (P = 0.013) and with family history of migraine (P = 0.003). | Emin Erdal et al., 2001 [13] |
-Migraine without aura (29) | |||||||
-Controls (30.7 ± 6.3) | |||||||
982 (346/636) | -Migraine (305) | 1468 | -Patients (46.8) | Norway, Caucasian | rs4680 | No association with migraine. | Hagen et al., 2006 [14] |
Association of the Val/Val genotype with non-migrainous headache in female patients (P = 0.04). | |||||||
-Non-migrainous headache (677) | |||||||
-Controls (55.5) | |||||||
219 | -Migraine with aura (92) | 144 | - | Germany Caucasian | rs4680 | No association. | Mössner et al., 2006 [15] |
-Migraine without aura (127) | |||||||
204 | -Chronic daily headache with drug abuse (103) | 117 | -Patients (range 23-81) | Italy Caucasian | rs4680 | No association. | Cevoli et al., 2006 [16] |
-Migraine without aura without drug abuse (101) | |||||||
-Controls (over 40) | |||||||
97 | Migraine without aura (97) | 94 | - | Korea Asian | rs4680 | Met allele associated with a higher pain intensity of headache (P = 0.001) and nausea/vomiting occurring (P = 0.026). | Park et al., 2007 [17] |
263 | Migraine without aura (55.9%) | 274 | -Patients (37 ± 16) | Spain Caucasian | rs2020917 | No association. | Corominas et al., 2009 [18] |
rs933271 | |||||||
rs1544325 | |||||||
259 | Migraine without aura (61.4%) | 287 | -Controls (55 ± 18) | rs740603 | |||
rs740601 | |||||||
rs4680 | |||||||
rs4646316 | |||||||
rs174696 | |||||||
rs165774 | |||||||
rs9332377 | |||||||
rs4485648 | |||||||
270 | Migraine with aura (270) | 272 | - | Germany Caucasian | rs933271 | No association. | Todt et al., 2009 [19] |
rs740603 | |||||||
rs4680 | |||||||
rs4646316 | |||||||
rs165774 | |||||||
rs5993889 | |||||||
1132 (240/892) | -Females with hormonally modulated migraine (464) | 608 (258/350) | Patients (range 18-50) | USA, White race ~ 90% | rs4680 | Significant association with migraine (P = 0.001) and hormonally modulated migraine (P = 0.03) | Sullivan et al., 2013 [20] |
Controls (range 19-50) | |||||||
-Females with nonhormonally modulated migraine (364) | |||||||
198 (40/158) | -1st cohort: Migraine without aura (75) | - | - | Italy Caucasian | rs4680 | Significant association between the Val/Val genotype and response to triptans. | Cargnin et al., 2013 [21] |
-2nd cohort: Migraine without aura (111) | |||||||
Migraine with aura (12) |