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Table 1 Reported association studies between COMT polymorphisms and migraine (pts: patients)

From: Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study

Patients (M/F)

Headache subtype

Healthy controls (M/F)

Mean age (years)

Country, Race-Ethnicity

Polymorphism

Comment

Reference

62 (11/51)

-Migraine with aura (33)

64 (14/50)

-Patients (32 ± 5.2)

Turkey, Asian

rs4680

Association between the Met allele and migraine (P = 0.013) and with family history of migraine (P = 0.003).

Emin Erdal et al., 2001 [13]

-Migraine without aura (29)

-Controls (30.7 ± 6.3)

982 (346/636)

-Migraine (305)

1468

-Patients (46.8)

Norway, Caucasian

rs4680

No association with migraine.

Hagen et al., 2006 [14]

Association of the Val/Val genotype with non-migrainous headache in female patients (P = 0.04).

-Non-migrainous headache (677)

-Controls (55.5)

219

-Migraine with aura (92)

144

-

Germany Caucasian

rs4680

No association.

Mössner et al., 2006 [15]

-Migraine without aura (127)

204

-Chronic daily headache with drug abuse (103)

117

-Patients (range 23-81)

Italy Caucasian

rs4680

No association.

Cevoli et al., 2006 [16]

-Migraine without aura without drug abuse (101)

-Controls (over 40)

97

Migraine without aura (97)

94

-

Korea Asian

rs4680

Met allele associated with a higher pain intensity of headache (P = 0.001) and nausea/vomiting occurring (P = 0.026).

Park et al., 2007 [17]

263

Migraine without aura (55.9%)

274

-Patients (37 ± 16)

Spain Caucasian

rs2020917

No association.

Corominas et al., 2009 [18]

rs933271

rs1544325

259

Migraine without aura (61.4%)

287

-Controls (55 ± 18)

rs740603

rs740601

rs4680

rs4646316

rs174696

rs165774

rs9332377

rs4485648

270

Migraine with aura (270)

272

-

Germany Caucasian

rs933271

No association.

Todt et al., 2009 [19]

rs740603

rs4680

rs4646316

rs165774

rs5993889

1132 (240/892)

-Females with hormonally modulated migraine (464)

608 (258/350)

Patients (range 18-50)

USA, White race ~ 90%

rs4680

Significant association with migraine (P = 0.001) and hormonally modulated migraine (P = 0.03)

Sullivan et al., 2013 [20]

Controls (range 19-50)

-Females with nonhormonally modulated migraine (364)

198 (40/158)

-1st cohort: Migraine without aura (75)

-

-

Italy Caucasian

rs4680

Significant association between the Val/Val genotype and response to triptans.

Cargnin et al., 2013 [21]

-2nd cohort: Migraine without aura (111)

Migraine with aura (12)