Case-control study of ADARB1 and ADARB2 gene variants in migraine

Table 5 Genotypic and allelic frequencies of migraine cases and controls and p-values derived from χ ² analysis for SNPs investigated in the ADARB1 and ADARB2 genes

SNP	Group	Genotypes			Total (n=)	Genotypic p-value	^a MAF	Allelic p-value	Hap-Map CEU ^a MAF
*ADARB1*		CC	GC	GG
rs2838771	Cases	0.429	0.441	0.130	261	0.86	0.35	0.65
	Controls	0.405	0.461	0.134	247		0.36		G allele, 0.36
		GG	GA	AA
rs407133	Cases	0.178	0.519	0.303	264	0.95	0.44	0.35
	Controls	0.179	0.529	0.292	291		0.44		G allele, 0.44
		CC	CA	AA
rs422720	Cases	0.157	0.498	0.345	255	0.64	0.42	0.35
	Controls	0.138	0.480	0.382	275		0.38		C allele, 0.38
		AA	AG	GG
rs1051367	Cases	0.277	0.530	0.193	274	0.53	0.46	0.40
	Controls	0.320	0.493	0.187	300		0.43		G allele, 0.43
*ADARB2*		AA	GA	GG
rs3793733	Cases	0.0	0.017	0.983	239	^b0.32	0.008	0.32
	Controls	0.0	0.031	0.969	228		0.015		A allele, 0.009
		AA	GA	GG
rs7070629	Cases	0.138	0.466	0.395	253	0.70	0.37	0.41
	Controls	0.125	0.444	0.430	279		0.35		A allele, 0.37
		TT	CT	CC
rs10903467	Cases	0.183	0.470	0.347	251	0.16	0.42	0.11
	Controls	0.205	0.524	0.271	288		0.47		T allele, 0.48
		TT	TA	AA
rs10903479	Cases	0.195	0.489	0.316	266	0.33	0.44	0.15
	Controls	0.153	0.490	0.357	294		0.40		T allele, 0.40
		TT	CT	CC
rs11250642	Cases	0.200	0.459	0.341	255	0.34	0.42	0.31
	Controls	0.200	0.500	0.300	270		0.45		T allele, 0.45
		GG	GT	TT
rs7094094	Cases	0.100	0.420	0.480	246	0.83	0.37	0.62
	Controls	0.104	0.442	0.454	269		0.33		G allele, 0.37
		AA	GA	GG
rs10903520	Cases	0.114	0.493	0.393	280	0.55	0.36	0.62
	Controls	0.144	0.476	0.380	290		0.38		A allele, 0.38
		GG	GC	CC
rs884861	Cases	0.161	0.435	0.404	248	0.16	0.38	0.05
	Controls	0.220	0.440	0.340	273		0.44		G allele, 0.43

^aMAF = Minor allele frequency.
^bHeterozygous GA genotype versus homozygous AA genotype only as no homozygous GG individuals were detected.

ISSN: 1129-2377