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Table 2 Proportion of patients who found daily activities to be ‘no more difficult than normal’ after treatment

From: Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies

Treatment

Proportion (%) of patients who found daily activities to be ‘no more difficult than normal’ after treatment

1 h

p-value

2 h

p-value

3 h

p-value

4 h

p-value

All headache episodes

AAC (n = 2734 – 2736 over 1 h – 4 h)

30.2

AAC vs. P

0.0001

47.8

AAC vs. P

<0.0001

64.8

AAC vs. P

<0.0001

76.1

AAC vs. P

<0.0001

APAP (n = 2738 – 2747 over 1 h – 4 h)

25.8

A vs. P

0.16

41.3

A vs. P

0.016

57.7

A vs. P

<0.0001

69.6

A vs. P

<0.0001

Placebo (n = 1367 – 1375 over 1 h – 4 h)

22.8

AAC vs. A

0.0005

36.3

AAC vs. A

<0.0001

51.0

AAC vs. A

<0.0001

60.9

AAC vs. A

<0.0001

Severe at baseline

AAC (n = 856 – 858 over 1 h – 4 h)

17.1

AAC vs. P

0.18

31.1

AAC vs. P

0.079

48.1

AAC vs. P

0.0001

62.5

AAC vs. P

<0.0001

APAP (n = 897 – 901 over 1 h – 4 h)

13.4

A vs. P

0.93

27.2

A vs. P

0.60

43.1

A vs. P

0.046

56.5

A vs. P

0.032

Placebo (n = 453 – 456 over 1 h – 4 h)

10.5

AAC vs. A

0.033

20.4

AAC vs. A

0.082

34.0

AAC vs. A

0.011

45.7

AAC vs. A

0.002

  1. AAC = acetylsalicylic acid, acetaminophen, caffeine; A or APAP = acetaminophen; P = placebo.