|
Treatment
|
Proportion (%) of patients who found daily activities to be ‘no more difficult than normal’ after treatment
|
|---|
|
1 h
|
p-value
|
2 h
|
p-value
|
3 h
|
p-value
|
4 h
|
p-value
|
|---|
|
All headache episodes
|
|
AAC (n = 2734 – 2736 over 1 h – 4 h)
|
30.2
|
AAC vs. P
|
0.0001
|
47.8
|
AAC vs. P
|
<0.0001
|
64.8
|
AAC vs. P
|
<0.0001
|
76.1
|
AAC vs. P
|
<0.0001
|
|
APAP (n = 2738 – 2747 over 1 h – 4 h)
|
25.8
|
A vs. P
|
0.16
|
41.3
|
A vs. P
|
0.016
|
57.7
|
A vs. P
|
<0.0001
|
69.6
|
A vs. P
|
<0.0001
|
|
Placebo (n = 1367 – 1375 over 1 h – 4 h)
|
22.8
|
AAC vs. A
|
0.0005
|
36.3
|
AAC vs. A
|
<0.0001
|
51.0
|
AAC vs. A
|
<0.0001
|
60.9
|
AAC vs. A
|
<0.0001
|
|
Severe at baseline
|
|
AAC (n = 856 – 858 over 1 h – 4 h)
|
17.1
|
AAC vs. P
|
0.18
|
31.1
|
AAC vs. P
|
0.079
|
48.1
|
AAC vs. P
|
0.0001
|
62.5
|
AAC vs. P
|
<0.0001
|
|
APAP (n = 897 – 901 over 1 h – 4 h)
|
13.4
|
A vs. P
|
0.93
|
27.2
|
A vs. P
|
0.60
|
43.1
|
A vs. P
|
0.046
|
56.5
|
A vs. P
|
0.032
|
|
Placebo (n = 453 – 456 over 1 h – 4 h)
|
10.5
|
AAC vs. A
|
0.033
|
20.4
|
AAC vs. A
|
0.082
|
34.0
|
AAC vs. A
|
0.011
|
45.7
|
AAC vs. A
|
0.002
|
- AAC = acetylsalicylic acid, acetaminophen, caffeine; A or APAP = acetaminophen; P = placebo.
