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Table 2 Proportion of patients who found daily activities to be ‘no more difficult than normal’ after treatment

From: Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies

Treatment Proportion (%) of patients who found daily activities to be ‘no more difficult than normal’ after treatment
1 h p-value 2 h p-value 3 h p-value 4 h p-value
All headache episodes
AAC (n = 2734 – 2736 over 1 h – 4 h) 30.2 AAC vs. P 0.0001 47.8 AAC vs. P <0.0001 64.8 AAC vs. P <0.0001 76.1 AAC vs. P <0.0001
APAP (n = 2738 – 2747 over 1 h – 4 h) 25.8 A vs. P 0.16 41.3 A vs. P 0.016 57.7 A vs. P <0.0001 69.6 A vs. P <0.0001
Placebo (n = 1367 – 1375 over 1 h – 4 h) 22.8 AAC vs. A 0.0005 36.3 AAC vs. A <0.0001 51.0 AAC vs. A <0.0001 60.9 AAC vs. A <0.0001
Severe at baseline
AAC (n = 856 – 858 over 1 h – 4 h) 17.1 AAC vs. P 0.18 31.1 AAC vs. P 0.079 48.1 AAC vs. P 0.0001 62.5 AAC vs. P <0.0001
APAP (n = 897 – 901 over 1 h – 4 h) 13.4 A vs. P 0.93 27.2 A vs. P 0.60 43.1 A vs. P 0.046 56.5 A vs. P 0.032
Placebo (n = 453 – 456 over 1 h – 4 h) 10.5 AAC vs. A 0.033 20.4 AAC vs. A 0.082 34.0 AAC vs. A 0.011 45.7 AAC vs. A 0.002
  1. AAC = acetylsalicylic acid, acetaminophen, caffeine; A or APAP = acetaminophen; P = placebo.