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Table 1 Pooled characteristics of all patients included in the efficacy evaluable population (i.e. all subjects who treated at least one headache in both treatment periods) in the four randomized, controlled studies included in the meta-analysis

From: Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies

Characteristic AAC APAP Placebo Total
Number of patients 1369 1376 689 1717
Number of headache episodes treated 2737 2748 1376 6861
Mean age (SD), y 34.1 (9.7) 34.1 (9.7) 34.5 (10.0) 34.2 (9.8)
Sex (F), n (%) 1129 (82.5) 1140 (82.9) 563 (81.7) 1416 (82.5)
Race, n (%)     
 Caucasian 1238 (90.4) 1245 (90.5) 625 (90.7) 1554 (90.5)
 Other 131 (9.6) 131 (9.5) 64 (9.3) 163 (9.5)
Mean no. headache episodes/month (SD) 6.4 (2.1) 6.4 (2.1) 6.4 (2.1) 6.4 (2.1)
Mean age at onset (SD), y 22.1 (8.7)a 22.2 (8.6)b 21.9 (8.6)c 22.1 (8.6)d
Onset, n (%)     
 Gradual 983 (71.9) 989 (71.9) 478 (69.4) 1225 (71.4)
 Rapid 385 (28.1) 386 (28.1) 211 (30.6) 491 (28.6)
Location, n (%)     
 Suboccipital 288 (21.0) 285 (20.7) 133 (19.3) 353 (20.6)
 Occipital 411 (30.0) 388 (28.2) 201 (29.2) 500 (29.1)
 Parietal 95 (6.9) 98 (7.1) 49 (7.1) 121 (7.1)
 Temporal 640 (46.8) 659 (47.9) 309 (44.9) 804 (46.8)
 Frontal 750 (54.8) 759 (55.2) 385 (55.9) 947 (55.2)
 Whole head 205 (15.0) 205 (14.9) 106 (15.4) 258 (15.0)
Character, n (%)     
 Non-throbbing 404 (29.5) 397 (28.9) 207 (30.0) 504 (29.4)
 Throbbing 341 (24.9) 343 (24.9) 182 (26.4) 433 (25.2)
 Combination 624 (45.6) 636 (46.2) 300 (43.5) 780 (45.4)
Usual severity (history), n (%)     
 Mild 12 (0.9) 8 (0.6) 8 (1.2) 14 (0.8)
 Moderate 789 (57.6) 784 (57.0) 375 (54.4) 974 (56.7)
 Severe 546 (39.9) 563 (40.9) 293 (42.5) 701 (40.8)
 Very severe 22 (1.6) 21 (1.5) 13 (1.9) 28 (1.6)
Severity at baseline, n (%)     
 Mild 0 (0.0) 1 (0.04) 0 (0.0) 1 (0.01)
 Moderate 1879 (68.7) 1846 (67.2) 920 (66.9) 4645 (67.7)
 Severe 858 (31.3) 901 (32.8) 456 (33.1) 2215 (32.3)
  1. Mean age at onset based on data from a1358 patients, b1364 patients, c684 patients, d1703 patients.
  2. AAC = acetylsalicylic acid, acetaminophen, caffeine; APAP = acetaminophen; SD = standard deviation.