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Figure 4 | The Journal of Headache and Pain

Figure 4

From: Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies

Figure 4

Proportion of all headache episodes and severe headache episodes at baseline with mild or no pain at 2 h after treatment. AAC was significantly superior to APAP and placebo for all headache episodes (p < 0.0001 for both) and for those that were severe at baseline (p = 0.0002 vs. APAP and p < 0.0001 vs. placebo). APAP was significantly superior to placebo (p < 0.0001) for all headache episodes and those that were severe at baseline (p = 0.003).

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