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Table 1 Human MMA, 100 mmHg, pre-contracted with PGF 2α

From: Comparison of the vasodilator responses of isolated human and rat middle meningeal arteries to migraine related compounds

Compound

Emax(%)

pEC50(M)

p - value

ACh (n = 6)

17 ± 6

N.A.

0.44

SNP (n = 6)

32 ± 6

~3.5

0.034

Sildenafil (n = 6)

11 ± 2

N.A.

0.91

PGE2 (n = 6)

8 ± 1

N.A.

0.62

PACAP-38 (n = 5)

9 ± 3

N.A.

0.89

CGRP (n = 4)

62 ± 8

8.1 ± 0.19

0.0015

NaCl (n = 4)

10 ± 4

N.A.

 
  1. p-value for comparing agonist versus the NaCl effect. N.A. = Not Applicable. Values are ± SEM, n given in parenthesis.
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The Journal of Headache and Pain

ISSN: 1129-2377

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