Figure 2From: The calcitonin gene-related peptide receptor antagonist MK-8825 decreases spinal trigeminal activity during nitroglycerin infusion Histograms showing mean neuronal activity. Activity was normalised to the baseline of 10 min periods (a) and of 30 min periods (b) in the MK-8825 group (grey bars, n = 12) and the vehicle group (black bars, n = 11); error bars are s.e.m. (c) Mean normalised activity (+ s.e.m.) of 6 units treated with nitroglycerin (GTN) alone for two hours. Significant differences in activity compared to the baseline periods (0–30 min) are indicated by a star and compared to periods after vehicle/MK-8825 infusion by #; repeated measures ANOVA and LSD post hoc test (a, b) or WILCOXON (c).Back to article page