Figure 2

Statistically significant differences within the DMN between patients with MwoA and HC groups. A) T-map of statistically significant differences within the DMN between patients with MwoA and HC groups (p < 0.05, cluster-level corrected) overlaid on the standard “Colin-27” brain T1 template. Talairach coordinates (x,y,z): top: right l-SPFG = −13, 43, 42; bottom: right l-TP = −34, 10, -14. B) Bar graphs of the ROI-averaged ICA z-scores (±SD) for patients with MwoA and HC groups. Top: l-SPFG (MwoA patients: 0.15 ± 0.63; HC: 2.12 ± 0.43; p = 0.01). Bottom: l-TP (MwoA patients: -0.09 ± 0.55; HC: 0.72 ± 0.29; p = 0.003). DMN: default mode network, MwoA: migraine without aura, HC: healthy controls, ICA: independent component analysis, l-SPFG: left superior prefrontal gyrus; l-TP: left temporal pole.