Table 2 Studies on endothelial function using flow-mediated dilation in migraineurs
Study (First author, year) | Study design | Patients included (n) | % women | Exclusion criteria | Migraine diagnosis | Results |
|---|---|---|---|---|---|---|
De Hoon, 2006 [20] | CC | Migraine: 10 | 60 | CVD, HYP, DM, dyslipidemia, CS | ICHD-I | No differences in FMD between migraineurs and controls |
Controls: 10 | ||||||
Hamed, 2010 [21] | CC | Migraine: 38 | 89 | CVD and vascular RF, DM, CS, alcoholism, active gastrointestinal disease, gout, epilepsy, recent infection, renal failure, pregnancy or lactation, regular use FANS or antimigrainous drugs and OC | ICHD-II | No differences in FMD between migraineurs and controls |
(MwA: 14; | ||||||
MwoA: 24) | ||||||
Controls: 35 | ||||||
Perko, 2011 [22] | CC | MwA: 20 | 80 | CVD, obesity, HYP, dyslipidemia, pregnancy or lactation and regular use of vasoactive drugs | ICHD-II | No differences in FMD between migraineurs and controls |
MwoA: 20 | ||||||
Controls: 20 | ||||||
Rodriguez-Osorio, 2012 [23] | CC | Migraine : 47 | 98 | CAD, inflammatory disease, obesity, HYP, DM, dyslipidemia, CS, infectious disease, severe systemic disease, ovarium pathology, pregnancy or lactation, use of vasoactive drugs | ICHD-II | No differences in FMD between migraineurs and controls |
(MwA:14; | ||||||
MwoA: 33) | ||||||
Controls: 23 | ||||||
Rossato, 2011 [24] | CC | Migraine: 20 | 75 | Age ≥50, vascular RF, CS, use of vasoactive drugs | Not reported | Decreased FMD in migraineurs |
Controls: 20 | ||||||
Silva, 2007 [25] | CC | Migraine: 50 (MwA: 25; MwoA: 25) | 88 | None | ICHD-II | No differences in FMD between migraineurs and controls |
Controls: 25 | ||||||
Thomsen, 1996 [26] | CC | MwoA: 12 | 100 | Use of any daily drugs | ICHD-I | No differences in FMD between migraineurs and controls |
Controls: 12 | ||||||
Vanmolkot, 2007 [27] | CC | Migraine: 50 | 78 | Age >50, CVD, HYP, obesity, DM, dyslipidemia, pregnancy or lactation, use of vasoactive drugs (except OC) | Validated questionnaire | Decreased FMD in migraineurs |
Controls: 50 | ||||||
Vernieri, 2010 [28] | CC | Migraine:21 | None | ICHD-II | FMD increased from controls to MwoA to MwA patients | |
(MwA: 11; MwoA: 10) | ||||||
Controls: 13 | ||||||
Yetkin, 2006 [29] | CC | Migraine: 45 | 80 | CAD, HYP, obesity, DM, infectious disease, ovarium pathology | ICHD-I | Decreased FMD in migraineurs |
Controls: 45 | ||||||
Yetkin, 2007 [30] | CC | Migraine: 24 | 89 | HYP, CAD, DM, infectious disease | ICHD-I | Decreased FMD in migraineurs |
Controls: 26 |