Author | No. of patients | Study design | Level of evidence | Mean age, year | Mean duration before treatment, year | Frequency of attacks per day before treatment | Pain severity before treatment, VAS | Mean follow- up, wk | Mean duration of effect, wk |
---|---|---|---|---|---|---|---|---|---|
Wu et al. [56] | 42 | Randomised, double-blind, placebo-controlled | 1b | 58.6 | 5.9 | 21.2 | 7.0 | 12 | At least 12 |
Bohluli et al. [57] | 15 | Open-label | 4 | 48.9 | 4.1 | 33.0 | 8.0 | 24 | At least 24 |
Zúñiga et al. [58] | 12 | Open-label | 4 | 58.5 | 6.2 | 23.4a | 8.8a | 8 | At least 8 |
Türk et al. [59] | 8 | Open-label | 4 | 57.1 | 1.6 | unclear | unclear | 24 | At least 24 |
Piovesan et al. [51] | 13 | Open-label | 4 | 61.8 | 8.8 | unclear | 9.9 | 8 | At least 8 |
Borodic et al. [60] | 11 | Open-label | 4 | 54.2 b | 10.0 | unclear | unclear | 30.6b | 5-12b |