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Table 2 Reported treatments for primary cough headache

From: Headache associated with cough: a review

Product [Reference]

Recommended daily dose

Most common side effects

Indomethacin [3]

50-150 mg

peptic ulcers, dyspepsia, edema, hyperkalemia, hypernatremia, hypertension

Topiramate [33]

50-100 mg

cognitive deficits, paresthesia, anorexia

Methysergide [9, 34, 35]

2 mg

pleuritis, pericarditis, retroperitoneal fibrosis

Acetazolamide [25]

375-2200 mg

paresthesia, parageusia, kidney stones, dehydration, headache, metabolic acidosis

Propranolol [35]

120 mg

hypotension, bradycardia

Naproxen [37]

550-1100 mg

gastrointestinal complaints

Metoclopramide [38]

10 mg intravenous bolus

restlessness, drowsiness, dizziness, fatigue, and focal dystonia