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Table 1 Efficacy data of primary outcomes

From: Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial

  Basal Nabilone Ibuprofen Follow-up
n 30 26 26 26
HI 0.95 ± 0.1 0.72 ± 0.3** 0.78 ± 0.3** 0.77 ± 0.3*
DAI 2.1 ± 1.4 0.89 ± 0.5**, 1.34 ± 0.9** 1.44 ± 1.1**
VAS 7.9 ± 1.6 5.7 ± 1.9**, 6.6 ± 2.2** 6.2 ± 2.4**
LP (h) 16.1 ± 7.1 8.7 ± 6.6** 10.4 ± 7.3* 11.1 ± 7.6**
LDQ 15.9 ± 6.3 9.2 ± 5.9**, 13.8 ± 6.6 11.9 ± 6.1*
PFD 2.1 ± 0.2 8.1 ± 9.3* 6.6 ± 6.3* 6.9 ± 6.3*
  1. Both drugs showed improvements in all outcomes, but nabilone was always more effective than ibuprofen, with statistically significant differences in DAI, VAS and LDQ values
  2. HI Headache Index, DAI daily analgesic intake, VAS Visual Analogue Scale, LP lasting of pain, LDQ Leeds Dependence Questionnaire, PFD pain free days/month
  3. Paired t test * p < 0.05 and ** p < 0.01 versus basal;  p < 0.05 versus ibuprofen