Fig. 1From: Future possibilities in migraine geneticsThe sequencing technique of choice in relation to the effect size and the population frequency of the variants. To find common (with a population frequency down to 5 %) and rare variants (population frequency of 1–2 %) with small effect size, many individuals are required while family-specific variants can be found by sequencing few individuals. Adapted from McCarthy et al. [44]Back to article page