Skip to main content

Table 1 Main clinical features of family members with ATP1A2 mutation

From: Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2)

Subject/gender/age (years) Onset, remission, (peak) (years) Lifetime occurrence (no. episodes) Aura Headache Accompanying symptoms Precipitating factors
Duration Type Location Laterality Duration (h) Character Laterality Intensity
III:6/F/(73) 15 (20–50) >100 15 min–1 h Scintillating scotoma; sensitive; motor; aphasic F, T, UL, LL, Tr Side-shifting 72 h Pressing/tightening Side-shifting Moderate N, V Menstruation.
Pregnancy.
IV:3/M/51 10, 44 (10–16) >40 15 min Zigzag lines; sensitive; aphasic. UL Side-shifting (90 % right) 6 h Throbbing Bilateral Moderate N, Pt, Pn Stress.
IV:4/M/48 16, 45 (26–30) >20 30–60 min Scintillating scotoma; sensitive; motor; aphasic; illusion of time-travel. F, T, UL, LL, Tr Bilateral (50 %) or Side-shifting (70 % right) 8 h Throbbing Side-shifting (70 % right) Severe N, V, Pt, Pn Sneezing Chocolate.
Heading.
IV:6/F/38 11 (36–38) >50 1 h–5 days Scintillating scotoma; sensitive; motor; aphasic; illusion of time-travel. F, T, UL, LL, Tr Side-shifting (80 % left) 24–72 h Throbbing Side-shifting (80 % left) Severe N, V, Pt, Pn, Dizziness Menstruation.
IV:7/F/35 9 (33–35) >30 15 min-16 days Scintillating scotoma; sensitive; motor; aphasic. F, T, UL, LL Side-shifting (80 % left) 30 min Pressing/tightening Side-shifting Moderate N, V, Pt, Pn, Menstruation,
chocolate, coffee.
Hitting a goal post with her head.
Immediate puerperium.
V:1/F/19 13, 15 2 15 min Sensitive; motor; aphasic. F, T, UL Side-shifting 30 min Pressing/tightening Bilateral Moderate N, Pt, Pn Facial trauma.
  1. F face, T tongue, UL upper limb, LL lower limb, Tr trunk, N nausea, V vomiting, Pt photophobia, Pn phonophobia, S somnolence