Table 1 Main clinical features of family members with ATP1A2 mutation
From: Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2)
Subject/gender/age (years) | Onset, remission, (peak) (years) | Lifetime occurrence (no. episodes) | Aura | Headache | Accompanying symptoms | Precipitating factors | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Duration | Type | Location | Laterality | Duration (h) | Character | Laterality | Intensity | |||||
III:6/F/(73) | 15 (20–50) | >100 | 15 min–1 h | Scintillating scotoma; sensitive; motor; aphasic | F, T, UL, LL, Tr | Side-shifting | 72 h | Pressing/tightening | Side-shifting | Moderate | N, V | Menstruation. Pregnancy. |
IV:3/M/51 | 10, 44 (10–16) | >40 | 15 min | Zigzag lines; sensitive; aphasic. | UL | Side-shifting (90 % right) | 6 h | Throbbing | Bilateral | Moderate | N, Pt, Pn | Stress. |
IV:4/M/48 | 16, 45 (26–30) | >20 | 30–60 min | Scintillating scotoma; sensitive; motor; aphasic; illusion of time-travel. | F, T, UL, LL, Tr | Bilateral (50 %) or Side-shifting (70 % right) | 8 h | Throbbing | Side-shifting (70 % right) | Severe | N, V, Pt, Pn Sneezing | Chocolate. Heading. |
IV:6/F/38 | 11 (36–38) | >50 | 1 h–5 days | Scintillating scotoma; sensitive; motor; aphasic; illusion of time-travel. | F, T, UL, LL, Tr | Side-shifting (80 % left) | 24–72 h | Throbbing | Side-shifting (80 % left) | Severe | N, V, Pt, Pn, Dizziness | Menstruation. |
IV:7/F/35 | 9 (33–35) | >30 | 15 min-16 days | Scintillating scotoma; sensitive; motor; aphasic. | F, T, UL, LL | Side-shifting (80 % left) | 30 min | Pressing/tightening | Side-shifting | Moderate | N, V, Pt, Pn, | Menstruation, chocolate, coffee. Hitting a goal post with her head. Immediate puerperium. |
V:1/F/19 | 13, 15 | 2 | 15 min | Sensitive; motor; aphasic. | F, T, UL | Side-shifting | 30 min | Pressing/tightening | Bilateral | Moderate | N, Pt, Pn | Facial trauma. |