Table 14 Level of evidence, scientific strength of evidence, clinical effectiveness, adverse events of preventive drug for Paroxysmal Headache

Indomethacin

25–50

C

0/+

+

–

1

[322]

Indomethacin

75

C

0/+

+++

Occasional, not severe

8

[323–330]

Indomethacin

150

C

0/+

+++

–

2

[330, 331]

Indomethacin

200–225

C

0/+

++

Occasional, not severe

3

[331, 332]

Verapamil

480

C

0/+

?

–

1

[333]

Piroxicam-β-cyclodextrine

20–40

C

0/+

++

–

6

[334]

Rofecoxib

25

C

0/+

+++

–

1

[317]

Rofecoxib

50

C

0/+

+++

Occasional, not severe

2

[317, 318]

Celecoxib

400

C

0/+

+++

–

1

[319]

Verapamil

240–320

C

0/+

++

–

10

[320]