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Table 1 Population characteristics and clinical features by study group

From: Late onset and early onset aura: the same disorder

 

Total

Early onset aura (EOA)

Late onset aura (LOA)

Statistics: Chi-Square, Fisher exact test or t test

N

77

51

26

 

Gender (F:M)

59:18

40:11

19:7

n.s.

Age at consultation (mean ± SD)

53.6 ± 7.8

50.5 ± 5.6

59.6 ± 8.2

t= −5.1,pa< 0.001

Age at aura onset (mean ± SD)

36.6 ± 19.1

25 ± 12.5

55.2 ± 11.6

t = −9.8, p< 0.001

Clinical diagnosis (AWMH:AwoMtH)

55:22

45:6

10:16

χ2(1) = 20.9, p < 0.001

Attacks of MWoA (Y:N)

48:29

31:20

17:9

n.s.

Attacks of AWnMH (Y:N)

11:66

9: 42

2:24

n.s.

Attacks of AWoMH (Y:N)

33:44

15:36

18:8

χ2(1) = 11.1, p = 0.001

“Aura status” (Y:N)

8:68

4:47

4:21

n.s.

Aura symptoms

 Visual (Y:N)

74:3

50:1

24:2

n.s.

  Only negative

11/65 (16.9%)

7/42 (16.7%)

4/23 (17.4%)

n.s.

  Only positive

15/65 (23%)

10/42 (23.8%)

5/23 (21.7%)

  Positive and negative symptoms

39/65 (60%)

25/42 (59.5%)

14/23 (60.9%)

 Somatosensory (Y:N)

19:58

14:37

5:21

n.s.

 Aphasia (Y:N)

21:56

12:39

9:17

n.s.

 Other (Y:N)

7:70

5:46

2:24

n.s.

 Multiple (Y:N)

22:54

13:38

9:16

n.s.

Aura fulfilling ICHD-II criteria (Y:N)

49:11

32 (91.4%):3

17 (68%):8

Fisher exact test, p < 0.05

Family history of migraine (Y:N)

43:24

28:15

15:9

n.s.

Follow-up time (years)

2.6 ± 4

2.3 ± 3.7

3.4 ± 4.5

p = n.s.

Co-morbidities

 Hypertension (Y:N)

24 (32.9%):49

11 (23.4%):36

13 (50%):13

χ2(1) = 5.36, p < 0.02

 Diabetes mellitus (Y:N)

1:72

1:47

0:25

n.s.

 Other cardiovascular disease (Y:N)

6:61

4:39

2:22

n.s.

 Depressive symptoms

25/66 (37.8%)

13/44 (29.5%)

12/22 (54.5%)

χ2(1) = 3.89, p < 0.05

 Sleep complaints (Y:N)

17:49

11:33

6:16

n.s.

 Seizures (Y:N)

4:51

4:38

0:13

Fisher exact test, p = n.s.

 Stroke (Y:N)

2:68

2:46

0:22

n.s.

 Vertigo (Y:N)

18:38

10:24

8:14

n.s.

Normal imaging (Y:N)

44:18

29:13

15:5

n.s.

 WMH (Y:N)

8:54

5:37

3:17

n.s.

 Vascular lesions (Y:N)

6:56

4:38

2:18

n.s.

 Non-vascular lesions (Y:N)

9:53

6:36

3:17

n.s.

Normal EEG (Y:N)

14:5

8:5

6:0

n.s.

  1. F females, M males, AWMH typical aura with migraine headache, AWnMH typical aura with non-migraine headache, AwoMH typical aura without migraine headache, AwoMtH aura without migraine-type headache (AWnMH + AwoMH), MWoA migraine without aura, WMH white matter hyperintensities