Fig. 3
From: Effect of CGRP and sumatriptan on the BOLD response in visual cortex
Top middle meningeal artery (MMA) circumference changes between baseline, after infusion of h-αCGRP or placebo and after subcutaneous sumatriptan 6 mg in 18 healthy subjects. There was significant 9% dilatation of MMA after CGRP compared to placebo (P = 0.006). Sumatriptan contracted the MMA by 25.2% (19.45–30.54%) on the CGRP day and 15% (7.66–22.34% CI) on the placebo day. Bottom middle cerebral artery (MCA) circumference changes between baseline, after infusion and after sumatriptan administration. MCA circumference did not differ between CGRP and placebo (P > 0.05). Sumatriptan contracted MCA by 3.9% (1.23–6.60% CI) on the CGRP day and by 5.3% (2.34–8.27% CI) after placebo. Y axis shows relative (%) changes compared to baseline while the present (%) values show relative changes between two measurements (baseline vs. infusion phase or infusion phase vs. after sumatriptan administration). Error bars indicate one-sided SEM. Reproduced with permission* from Asghar et al. (Neurology 2010;75(17):1520–1526) (*Permission has been requested)