Fig. 1
From: Effect of CGRP and sumatriptan on the BOLD response in visual cortex
a The experimental paradigm. Baseline recordings were performed at T−5min. All participants randomly received infusion of CGRP (1.5 g/min) or placebo over 20 min. Injection of sumatriptan was given at T42min. T1-weighted 3D anatomical images were obtained at T−15min. BOLD-fMRI recordings were performed at baseline, T5min, T15min, T25min, T35min, T45min, T55min and T65min. MR-angiography’s of the middle meningeal artery and middle cerebral artery were recorded at baseline, T30min and T60min. Headache scores, blood pressure (BP), heart rate, end-tidal \( {\text{P}}_{{{\text{CO}}_{ 2} }} \) and adverse events (AEs) were recorded at baseline, T3min, T10min, T20min, T40min, T50min, T70min and T75min. b Group analysis of the baseline scans (before drug infusion) of 18 healthy subjects on CGRP study day. The images show at strong activation in the visual cortex after visual stimulation (arrows). Group analysis from the placebo day showed similar results