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Table 8 Prophylactic migraine medication, second- and third-line medications [10] and recommended doses

From: Reference programme: Diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 2nd Edition, 2012

Medicinal product

Daily dose

Second-line

 Amitriptyline

10–100 mg

 Naproxen

500 mg ×2

 Bisoprolol

5–10 mg

Third-line

 Candesartan

16 mg

 Lisinopril

20 mg

 Acetylsalicylic acid

300 mg

 Magnesium

360 mg

 Riboflavine

400 mg

 Methysergide

4–12 mg

 Gabapentin

1,200–1,600 mg

 Pitzotifen

1.5–3 mg