Table 1 Overview of published GWAS in migraine

Discovery samples

Names

?,?, LUMINA

ERF, NESDA, NTR1, NTR2, Rotterdam study, AGES study

WGHS

Origin

Clinic-based; Finland, Germany, The Netherlands

Population-based; The Netherlands, Iceland

Population-based; US, European descent

# of migraineurs/non-migraineurs

2,731/10,747

2,446/8,534

5,122/18,108

Implicated gene variants (gene)^a

rs1835740 (between MTDH and PGCP)

rs9908234 (NGFR)

rs2651899 (PRDM16)

rs2078371 (–)

rs10166942 (TRPM8)

rs17172526 (SEPT7)

rs2203834 (C8orf79)

rs13290757 (–)

rs11172113 (LRP1)

Replication samples

Names

?, ?, ?, LUMINA

GEM, NTR3, ATM

GEM, SHIP, IHGC

Origin

Clinic- and population-based/Denmark, Iceland, Germany, The Netherlands

Population-based/The Netherlands, Australia

Population-based/The Netherlands, Germany; clinic-based/Europe

# of migraineurs/non-migraineurs

3,202/40,062

2,957/5,774

3,828/13,949

Replicated gene variants

rs1835740 (between MTDH and PGCP)

None

rs2651899 (PRDM16) rs10166942 (TRPM8) rs11172113 (LRP1)

Meta-analysis among

Discovery and replication samples

Discovery samples

Discovery and replication samples

Pooled results^a

rs1835740: OR = 1.18, 95% CI 1.13–1.24, p = 1.69 × 10⁻¹¹

rs9908234: p = 8.00 × 10⁻⁸

rs2651899: OR = 1.11, 95% CI 1.07–1.15, p = 3.8 × 10⁻⁹

rs10166942: OR = 0.85, 95% CI 0.82–0.89, p = 5.5 × 10⁻¹²

rs11172113: OR = 0.90, 95% CI 0.87–0.93, p = 4.3 × 10⁻⁹

Other implicated gene variants in discovery samples

Significance threshold

p ≤ 5 × 10⁻⁵

p < 10⁻⁵

p < 5 × 10⁻⁶

Gene variants (genes)^a

rs12084862 (SMYD3)

31 other SNPs including:

rs2078371 (–)

rs17528324 (INSIG2)

rs11636768 (AGBL1)

rs17172526 (SEPT7)

rs17862920 (TRPM8)

rs10275320 (MACC1)

rs2203834 (C8orf79)

rs2038761 (MYLK4)

rs4939879 (LIPG)

rs13290757 (–)

rs6456880 (ZNF311)

rs4861775 (AGA)

rs7753655 (–)

rs986222 (KIF2OB)

rs10888075 (near SGCZ)

rs6107848 (BMP2)

rs10111769 (–)

rs140174 (IGLL1)

rs2042600 (NAV2)

rs1146161 (TSPAN2)

rs3794331 (COG3)

rs4742323 (KDM4C)

rs473422 (near AQP9)