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Table 2 Tolerability and side effect profile

From: Topiramate plus nortriptyline in the preventive treatment of migraine: a controlled study for nonresponders

Groups

Adverse events (%)

TPM + NTP

 

 65.9%

Dry mouth 18.2%

Weight loss 11.4%

Paresthesia 13.6%

Somnolence 9.1%

Weight gain 6.8%

Hair loss 2.3%

Heartburn 2.3%

Dry mouth 4.5%

Memory disturbances 6.8%

Paresthesia and weight loss 9.1%

Paresthesia. weight loss and memory disturbances 6.8%

TPM + placebo

 

 41.2%

Weight loss 17.6%

Paresthesia 11.8%

Weight gain 11.8%

NTP + Placebo

 

 36.8%

Weight gain 31.6%

Hair loss 10.5%

Weight gain and hair loss 5.3%