Skip to main content

Table 1 Differences between headache preceded by infection and headache with no prior history of recent infection

From: Post-infectious headache: a reactive headache?

Parameters Headache preceded by infection (n = 23) Headache with no prior history of recent infection (n = 11)
Age (years) (mean, range) 32.5 ± 12.6, 17–55 34.8 ± 14.5
Sex (F:M) 12:11 6:05
Duration of headache (weeks)
 1–2 10 (44%) 4 (36%)
 2–3 7 (30%) 4 (36%)
 3–4 6 (26%) 3 (27%)
Location of pain
 Holocephalic 10 (44%) 5 (46%)
 Parieto occipital 8 (35%) 3 (27%)
 Fronto temporal 5 (22%) 3 (27%)
 With neck pain 14 (61%) 4 (36%)
Quality of pain
 Pressing 17 (74%) 8 (73%)
 Throbbing 6 (26%) 3 (27%)
Variability of headache
 Intermittent daily pain 5 (22%) 4 (36%)
 Constant with no or little fluctuations 14 (61%) 6 (55%)
 Constant with frequent exacerbations 4 (17%) 1 (9%)
Severity
 Mild to moderate 21 (91%) 9 (82%)
 Severe 2 (9%) 2 (18%)
Associated symptoms and signs
 Nausea 7 (30%) 2 (18%)
 Photophobia 7 (30%) 2 (18%)
 Phonophobia 2 (9%) 1 (9%)
 Cranial autonomic feature 1 (4%) 0
 Meningeal sign 9 (39%) 3 (27%)
 Body pain 5 (22%) 2 (18%)
Neuroimaging
 Normal 13/13 4/4
CSF examinations
 Pleocytosis 3/9 0/3
Provisional diagnosis (at the time of presentation)
 Probable migraine 8 4
 Probable CTTH 11 6
 Probable NDPH 4 1
Treatment
 Dothiepin 12 6
 Amitriptyline 4 5
 Valproate 7 4
 Propranolol 4 0
 Leviteracetam 3 0
 Paracetamol 8 5
 Naproxen 15 6
 Indomethacin 5 1
 Steroids 10 2
Follow-up and treatment response
 At 3 months
  Complete response 8 (35%) 6 (55%)
  Marked response with episodic headaches (1–5 attacks/week) 10 (43%) 4 (36%)
  No or minimal response 5 (22%) 1 (9%)
 Response to steroids (at 3 months) (10 patients) (2 patients)
  Marked and immediate 4/10 (40%) 0/2
  Moderate response 3/10 (30%) 1/2
  Mild to no response 3/10 (30%) 1/2
 Response to steroids (IV MPS) (at 9 months) (7 patients) (2 patients)
  Marked and immediate 3/7 (42%) 0/2
  Moderate response 2/7 (29%) 1/2
  Mild to no response 2/7 (29%) 1/2