Drug or fixed-dose combination | Quality of the scientific evidence | Scientific evidence of efficacy | Clinical impression of effectiveness | Clinical impression of tolerability | Commentary | Recommendation for self-medication |
---|---|---|---|---|---|---|
Two tablets of the fixed combination: acetylsalicylic acid (250–265 mg) + paracetamol (200–265 mg) + caffeine (50–65 mg) | A | +++ | ++ | +++ | Highlighted recommendation on the basis of the analysed comparative studies | Drug of first choice |
Acetylsalicylic acid 1,000 mg | A | ++ | ++ | ++ | Drug of first choice | |
Diclofenac 12.5 mg | A | ++ | ++ | ++ | Drug of first choice | |
Diclofenac 25 mg | A | ++ | ++ | ++ | Only in Germany since 2007 prescription free | Drug of first choice |
Ibuprofen 400 mg | A | ++ | ++ | +++ | For 200 mg ibuprofen no data on efficacy | Drug of first choice |
Two tablets of the fixed combination: paracetamol (500 mg) + caffeine (65 mg) | A | ++ | ++ | +++ | Drug of first choice | |
Paracetamol 1,000 mg | B | + | + | +++ | Drug of second choice | |
Acetylsalicylic acid + paracetamol | C | (+) | ++ | +++ | Only in individual cases | |
Acetylsalicylic acid + vitamin C | D | 0 | ++ | ++ | Only in individual cases | |
Naproxen resp. naproxen sodium | D | 0 | + | ++ | Efficacy from 200 to 250 mg naproxen or naproxen-sodium is not proofed | Only in individual cases |
Phenazone or phenazone-containing combinations | D | 0 | + | ++ | Only in individual cases | |
Propyphenazone mono or in combinations | D | 0 | + | ++ | Only in individual cases |