STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses

Table 4 Allele model: pooled and meta-analyses of the association between the SLC6A4 STin2 VNTR polymorphism and migraine

Migraine category	Study populations	No. of studies	Pooled analysis	Meta-analysis
			Odds ratio^a (95% CI)	Odds ratio^a (95% CI)	Heterogeneity				Publication bias
			Odds ratio^a (95% CI)	Odds ratio^a (95% CI)	Q	df	p value	I² in %	p value, Begg	p value, Egger
Any migraine	All [9, 10, 12, 13]	4	0.95 (0.81–1.11)	1.00 (0.72–1.41)	10.1	3	0.02	70.4	0.17	0.045
Any migraine	European descent [10, 12, 13]	3	0.89 (0.76–1.05)	0.85 (0.70–1.02)	1.3	2	0.54	0	0.60	0.63
MA	European descent [10–13]^b	4	0.93 (0.76–1.14)	0.83 (0.66–1.05)	2.7	3	0.44	0	0.50	0.17
MO	European descent [10, 12, 13]^b	3	0.88 (0.72–1.08)	0.86 (0.69–1.08)	1.5	2	0.48	0	0.12	0.01

MA migraine with aura, MO migraine without aura
^aSTin2.9 and STin2.10 alleles were grouped together and compared to STin2.12 as the reference
^bThere are no studies available for MA and MO among populations of non-European descent

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