STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses

Schürks, Markus; Rist, Pamela M.; Kurth, Tobias

doi:10.1007/s10194-010-0230-3

The Journal of Headache and Pain

Table 3 Odds ratios (95% confidence intervals) and Hardy–Weinberg equilibrium for the association between the SLC6A4 STin2 VNTR polymorphism and migraine

From: STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses

Author	Disease status	Study size	Allele model^a		Genotype model^b
			OR (95% CI)	p value	HWE	STin2.10/STin2.12		STin2.10/STin2.10		Other^c
			OR (95% CI)	p value	HWE	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value
Ogilvie [10]	Controls	133	Referent		0.48	Referent		Referent		Referent
	Any migraine	285	0.77 (0.57–1.04)	0.09	–	0.52 (0.33–0.82)	0.005	0.67 (0.35–1.29)	0.23	1.57 (0.43–5.72)	0.50
	MA	94	0.88 (0.60–1.29)	0.51	–	0.49 (0.27–0.90)	0.02	0.83 (0.37–1.84)	0.64	2.10 (0.50–8.95)	0.32
	MO	173	0.74 (0.54–1.03)	0.08	–	0.56 (0.34–0.92)	0.02	0.65 (0.32–1.33)	0.23	1.12 (0.27–4.70)	0.88
Lea [13]	Controls	141	Referent		0.0001	Referent		Referent		Referent
	Any migraine	148	0.99 (0.71–1.38)	0.95	–	0.96 (0.56–1.65)	0.87	0.97 (0.53–1.75)	0.91	1.17 (0.30–4.57)	0.82
	MA	81	1.01 (0.68–1.49)	0.96	–	0.96 (0.51–1.84)	0.91	1.00 (0.50–2.02)	1.00	1.30 (0.28–6.16)	0.74
	MO	67	0.97 (0.64–1.47)	0.87	–	0.95 (0.48–1.88)	0.88	0.93 (0.44–1.97)	0.84	1.02 (0.18–5.88)	0.98
Yilmaz [9]	Controls	79	Referent		0.01	Referent		Referent		Referent
Yilmaz [9]	Any migraine	37	2.09 (1.19–3.67)	0.01	–	3.20 (1.25–8.22)	0.02	3.18 (1.07–9.41)	0.04	–^d	–^d
Racchi [11]	Controls	32	Referent		0.28	Referent		Referent		Referent
Racchi [11]	MA	44	0.66 (0.35–1.27)	0.21	–	1.81 (0.61–5.42)	0.29	0.25 (0.05–1.20)	0.08	–^d	–^d
Szilagyi [12]	Controls	464	Referent		0.42	Referent		Referent		Referent
	Any migraine	87	0.81 (0.58–1.15)	0.24	–	0.78 (0.48–1.28)	0.33	0.61 (0.27–1.39)	0.24	1.05 (0.28–3.85)	0.95
	MA	38	0.62 (0.37–1.05)	0.07	–	0.51 (0.25–1.05)	0.07	0.44 (0.13–1.53)	0.19	1.32 (0.28–6.29)	0.72
	MO	49	0.99 (0.64–1.52)	0.96	–	1.09 (0.57–2.06)	0.80	0.81 (0.29–2.28)	0.69	0.74 (0.09–5.95)	0.77

HWEp value for Hardy–Weinberg equilibrium, MA migraine with aura, MO migraine without aura
^aCompares STin2.9 and STin2.10 versus STin2.12 alleles
^bCompares each of the genotypes versus the STin2.12/STin2.12 genotype
^cSTin2.9/STin2.10 and STin2.9/STin2.12
^dIn some groups there were no other genotypes

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