Migraine treatment in developmental age: guidelines update

Papetti, Laura; Spalice, Alberto; Nicita, Francesco; Paolino, Maria Chiara; Castaldo, Rosa; Iannetti, Paola; Villa, Maria Pia; Parisi, Pasquale

doi:10.1007/s10194-010-0205-4

The Journal of Headache and Pain

Table 3 Symptomatic drugs evaluated in placebo-controlled and open clinical trials

From: Migraine treatment in developmental age: guidelines update

Drug	Evidence level	Study design	Ages (years)	n	Primary end point: pain relief (hours)	Responders (%)	Placebo responses (%)	P value	Author/Pubdate/Ref.
Ibuprofen
10 mg/kg	A	rDBPC	4–16	88	2	68	37	<0.05	Hamalainen et al., 1997 [10, 16]
7.5 mg/kg		DBPC	6–12	84	2	76	53	0.006	Lewis et al., 2002 [10, 16]
200–400 mg		DBPCCO	6–18	32	2	69	28	<0.05	Evers et al., 2006 [21]
Acetaminophen
15 mg/kg	B	rDBPC	4–16	88	2	54	37	<0.05	Hamalainen et al., 1997 [10, 16]
Sumatriptan nasal
20 mg	A	rDBPC	6–10	14	2	86	42.8	0.03	Ueberall et al., 1999 [18]
5–10–20 mg		rDBPC	12–17	510	2	63–66	53	<0.05	Winner et al., 2000 [18]
10–20 mg		rDBPCCO	8–17	83	2	64	39	0.003	Ahonen et al., 2004 [18]
20 mg		rDBPC	12–17	738	1	61	52	ns	Winner et al., 2006 [19]
Sumatriptan oral
50–100 mg	C	rDBPCCO	8–16	23	2	30	22	ns	Hamalainen et al., 1997 [10, 16]
Sumatriptan subcutaneous
3–6 mg	C	OL	6–16	17	2	64	–	–	MacDonald, 1994 [10, 16]
0.06 mg/kg	C	OL	6–18	50	2	78	–	–	Linder, 1996 [10, 16]
Zolmitriptan oral
2.5–5 mg	C	OL	12–17	38	2	88	–	–	Linder et al., 2000 [10, 16]
2.5 mg		DBPCCO	6–18	32	2	62	28	P < 0.05	Evers et al., 2006 [21]
2.5–5–10 mg		rDBPC	12–17	850	2	53–57	58	ns	Rothner et al., 2006 [20]
Zolmitriptan NS
5 mg	B	SB-DBPC	12–17	171	1	58.1	43.3	P < 0.05	Lewis et al., 2007 [22]
Rizatriptan oral
5 mg	C	rDBPC	12–17	296	2	66	56	ns	Winner et al., 2002 [10, 16]
5 mg		rDBPC	12–17	234	2	68.2	68.8	ns	Visser et al., 2004 [23]
5 mg		OL	12–17	686	2	77	–	–	Visser et al., 2004 [23]
5–10 mg		rDBPC	6–17	96	2	74	36	P = 0.001	Ahonen et al., 2006 [24]
Almotriptan oral
6.25–12.5 mg	B	OL	11–17	15	2	85	–	–	Charles et al., 2006 [25]
6.25–12.5–25 mg	B	rDBPC	12–17	866	2	67–73	55	P < 0.001	Linder et al., 2008 [26]
Eletriptan oral
40 mg	C	DBPC	12–17	267	2	57	57	ns	Winner et al., 2007 [27]
Naratriptan oral	C	DBPC	12–17	300	4	64–72	65	ns	Rothner et al., 1997 [10, 16]

DBPC double-blind placebo-controlled, DBPCCO double-blind placebo-controlled crossover, rDBPC randomized double-blind placebo controlled, HA headache, OL open-label, RR retrospective review

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ISSN: 1129-2377

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