Table 1 Main features of patients 4–9
From: Post-infectious new daily persistent headache may respond to intravenous methylprednisolone
Case 4 | Case 5 | Case 6 | Case 7 | Case 8 | Case 9 | |
|---|---|---|---|---|---|---|
Age (year) | 24 | 26 | 32 | 25 | 29 | 20 |
Sex | M | M | F | M | M | F |
Duration of headache (weeks) | 6 | 16 | 20 | 10 | 14 | 10 |
Details of headache | hol, press, cont, mod, occ. exacer | hol, press, cont, mild-mod | hol, press, cont, mild-mod, occ. exacer | hol, press, occ, puls, cont, mod, occ. exacer | hol, press, cont, mild-mod | hol, press, cont, mild-mod |
Associated symptoms | No | nau, phot | No | nau | nau, phot | No |
Preceding illness | ||||||
Type of illness | Rhinitis | Pharyngitis | Pharyngitis | Gastroent | Rhinitis | Gastroent |
Time interval with headache onset (weeks) | 4 | 5 | 3 | 2 | 3 | 3 |
Duration of illness | 3–4 days | 10 days | 2 weeks | 2–3 days | 1 weeks | 4–5 days |
Any investigations | Not done | Normal | Leucocytosis | Not done | Not done | Not done |
Treatment | cetr, para | antb, ibup | antb, para | Not any specific | Detail not known | Metr |
Investigations | ||||||
MRI brain | Normal | Normal | Normal | Normal | Normal | Normal |
(use of contrast) | No (at 6 weeks) | No (at 12 weeks) | No (at 20 weeks) | Yes (at 9 weeks) | Yes (at 14 weeks) | Yes (at 10 weeks) |
CSF | Normal | Not done | Not done | Normal | Not done | Normal |
Others | Normal | Normal | Normal | Normal | Normal | Normal |
Prior treatments | ||||||
Drugs used | amt, val, nap, ind | ibu, nap, top, dot, pred | ibu, ind, pro, amt, pred | amt, Ibu, para, | ibu, nap, ind | para, val, amt |
Response | No | Minimal | Minimal | No | Minimal | No |
Treat. with IV MPS (1,000 mg daily) | 5 days | 5 days | 5 days | 5 days | 5 days | 5 days |
Followed with oral prednisolone | No | 40 mg/d for 3 weeks | 60 mg/d for 3 weeks | No | 40 mg/d for 2 weeks | 60 mg/d for 2 weeks |
Beginning of response | 2nd day of infusion | 4th day of infusion | 5th day of infusion | 3rd day of infusion | 4th day of infusion | 3rd day of infusion |
Total response | com in 2 weeks | mar in 1 week, com in 2 weeks | mar in 2 weeks | mar in 1 week | mar in 1 week, com in 2 weeks | com in 2 weeks |
Follow up | no hd in 3 months | occ. mild hd in 3 mths. No after that in next 3 months | occ. mild-mod, hd in next 8 weeks. No after that in next 4 months | occ. mild hd in 6 weeks. No hd in next 4 months | no hd in 4 months | no hd in 6 months |