Table 2 Genotypic and allelic frequencies of 5-HT1B polymorphism in controls, migraine without aura and without drug overuse (MO) and medication overuse headache (MOH)
From: Lack of association between five serotonin metabolism-related genes and medication overuse headache
|  | Controls (n = 104) | MO (n = 107) | MOH (n = 105) |
|---|---|---|---|
n (%) | n (%) | n (%) | |
5-HT1B (−261) genotype | |||
 GG | 21 (0.20) | 23 (0.22) | 16 (0.15) |
 GT | 44 (0.42) | 44 (0.41) | 46 (0.44) |
 TT | 39 (0.38) | 40 (0.37) | 43 (0.41) |
MO versus controls | χ2 = 0.061 (P = 0.970) | ||
MOH versus controls | χ2 = 0.913 (P = 0.634) | ||
MOH versus MO | χ2 = 1.397 (P = 0.497) | ||
5-HT1B alleles | |||
 G | 81 (0.43) | 81 (0.42) | 119 (0.62) |
 T | 105 (0.57) | 111 (0.58) | 73 (0.38) |
MO versus controls | χ2 = 0.02 (P = 0.883) | ||
MOH versus controls | χ2 = 0.77 (P = 0.379) | ||
MOH versus MO | χ2 = 1.07 (P = 0.302) | ||
|  | Controls (n = 103) | MO (n = 110) | MOH (n = 110) |
|---|---|---|---|
n (%) | n (%) | n (%) | |
5-HT1B (861) genotype | |||
 GG | 50 (0.48) | 57 (0.52) | 62 (0.56) |
 GC | 48 (0.47) | 46 (0.42) | 44 (0.40) |
 CC | 5 (0.05) | 7 (0.06) | 4 (0.04) |
MO versus controls | χ2 = 0.606 (P = 0.739) | ||
MOH versus controls | χ2 = 1.343 (P = 0.511) | ||
MOH versus MO | χ2 = 1.083 (P= 0.582) | ||
5-HT1B alleles | |||
 G | 124 (0.69) | 105 (0.68) | 114 (0.66) |
 C | 56 (0.31) | 49 (0.32) | 58 (0.34) |
MO versus controls | χ2 = 0.04 (P = 0.839) | ||
MOH versus controls | χ2 = 1.13 (P = 0.288) | ||
MOH versus MO | χ2 = 0.76 (P = 0.382) | ||