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Table 4 Preventive treatments in headache associated with depressive syndrome

From: Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide risk

Preventive treatment
 Migraine + depression + anxious symptoms: antidepressants with sedative properties
  TCAs: amitriptyline
  SSRIs: paroxetine, fluvoxamine
  SNRIs: mirtazepine
 Migraine + depression with psychomotor slowing: antidepressants without sedative properties
  SSRIs: fluoxetine
Inadvisable drugs
 Flunarizine
 Beta-blockers