Meeting patient expectations in migraine treatment: what are the key endpoints?

Table 1 How the AwM study results meet patient expectations. Adapted from [12]

Patients-sought attribute of treatment	AwM study outcome variables (still mild vs. moderate-severe)^a
1. Complete relief	1. Increased 2 h pain-free status
2. Fast onset of pain relief	2. Shorter duration of migraine attack
3. Rapid restoration of normal functioning	3. Faster achievement of pain-free status
4. Relief of associated symptoms	4. Early pain relief within 0–2 h^b
5. No recurrence	5. Reduced duration of migraine pain
6. Absence of side effects	6. Less time lost in daily activities
	7. Reduced nausea, vomiting, phono-photo- and osmophobia
	8. Higher sustained pain-free state
	9. Less use of rescue medication
	10. Placebo-like safety and tolerability

^aPoints 1 and 3 column on the right show only a trend to significance, points 4, 7, 9 not covered in [12] but could be evidence
^bMeasured in mild-moderate pain for almotriptan versus placebo

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