Fig. 1
From: A review of diagnostic and functional imaging in headache
The pain matrix mainly consists of the thalamus (Th), the amygdala (Amyg), the insula cortex (Insula), the supplementary motor area (SMA), the posterior parietal cortex (PPC), the prefrontal cortex (PFC), the cingulate cortex (ACC), the periaqueductal grey (PAG), the basal ganglia and cerebellar cortex (not shown) and the primary (S1) and secondary (S2, not shown) sensory cortex. For review see Refs. [19, 20]