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First Springer Nature AI-generated book in medicine now available!

The book Migraine in Medicine edited by Paolo Martelletti is now available. This is the first Springer Nature AI-generated book in medicine. Read more…

Visual Abstracts

The Journal of Headache and Pain encourages authors to submit a visual abstract along with their manuscripts. 

As an author submitting at The Journal of Headache and Pain you are entitled to a 20% discount on professionally produced visual abstracts. Click here to find out more about the service, and your discount will be automatically applied when using this link.

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Aims and scope

The Journal of Headache and Pain is a peer-reviewed open access journal specifically dedicated to researchers involved in all aspects of headache and related pain syndromes, including epidemiology, public health, basic science, translational medicine, clinical trials and real-world data. With a multidisciplinary perspective, The Journal of Headache and Pain covers headache medicine and related pain syndromes in all medical disciplines and particularly encourages clinical, translational and basic science submissions in the areas of pain management, genetics, neurology and internal medicine. Read more


  1. Authors: Claudio Tana, Enrico Bentivegna, Soo-Jin Cho, Andrea M. Harriott, David García-Azorín, Alejandro Labastida-Ramirez, Raffaele Ornello, Bianca Raffaelli, Eloísa Rubio Beltrán, Ruth Ruscheweyh and Paolo Martelletti

Consensus article | 16 January 2019
European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention
Simona Sacco, Lars Bendtsen, Messoud Ashina, Uwe Reuter, Gisela Terwindt, Dimos-Dimitrios Mitsikostas and Paolo Martelletti

Consensus article | 21 May 2019
Aids to management of headache disorders in primary care (2nd edition) 
on behalf of the European Headache Federation and Lifting The Burden: the Global Campaign against Headache
T. J. Steiner, R. Jensen, Z. Katsarava, M. Linde, E. A. MacGregor, V. Osipova, K. Paemeleire, J. Olesen, M. Peters & P. Martelletti

Review article | 25 April 2019
A narrative review on the burden of migraine: when the burden is the impact on people’s life
Matilde Leonardi & Alberto Raggi

Research article | 07 April 2020
Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy
Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia & Simona Sacco

Review article | 09 May 2019
Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications
Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello & Gianluca Serafini on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)

Review article | 13 February 2020
Gut-brain Axis and migraine headache: a comprehensive review
Mahsa Arzani, Soodeh Razeghi Jahromi, Zeinab Ghorbani, Fahimeh Vahabizad, Paolo Martelletti, Amir Ghaemi, Simona Sacco & Mansoureh Togha On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)

Review article | 30 August 2019
Current and emerging evidence-based treatment options in chronic migraine: a narrative review
Elio Clemente Agostoni, Piero Barbanti, Paolo Calabresi, Bruno Colombo, Pietro Cortelli, Fabio Frediani, Pietrangelo Geppetti, Licia Grazzi, Massimo Leone, Paolo Martelletti, Luigi Alberto Pini, Maria Pia Prudenzano, Paola Sarchielli, Gioacchino Tedeschi, Antonio Russo & The Italian chronic migraine group

Editorial | 02 December 2020
Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019
T. J. Steiner, L. J. Stovner, R. Jensen, D. Uluduz & Z. Katsarava on behalf of Lifting The Burden: the Global Campaign against Headache

Review article | 17 April 2019
Therapeutic novelties in migraine: new drugs, new hope? 
Thien Phu Do, Song Guo & Messoud Ashina

Research article | 29 July 2020
Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study
Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente, Juan Francisco Arenillas & Ángel L. Guerrero

Research article | 01 June 2020
A prospective real-world analysis of erenumab in refractory chronic migraine
Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova & Anna P. Andreou

Publication years: 2019-2020
Source: Web of Science, data collected: February 2022

Trending articles

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Editorial Office

Editor-in-Chief (Founding)

Prof. Paolo Martelletti, MD

Department of Clinical and Molecular Medicine

Sapienza University of Rome, Italy


European Headache Federation School of Advanced Studies

Read the latest review article by Matteo Castaldo and Marta Waliszewska‑Prosół et al. published in the collection Hot topics in headache and pain from the EHF-SAS

Key messages of the review are nicely presented in the visual abstract below!

New Content Item (2)

The European Headache Federation School of Advanced Studies (EHF-SAS) aims to support headache science and offers young EU scientists high quality educational activities to enhance their critical spirit and skills to face headache medicine from a multidisciplinary perspective.

The EHF-SAS covers the richness and diversity of headache medicine fields, including basic science, clinical science, and diagnostic science, and places an emphasis on collaborative projects. The European Headache Federation will support its fellows’ activities allowing them to independently build their own plan sided by the EHF-SAS Scientific Committee.

Call for papers

Real-world evidence of emerging therapies in headache

New Content ItemEdited by: Shuu-Jiun Wang and Michel Lanteri-Minet  

The aim of this thematic series is to collect high quality real-world data within the headache field.  Read more about the scope of the series and contribute with your own research and review articles.

Molecular interactions in migraine

EditNew Content Itemed by Rashid Giniatullin

The aim of this thematic series is to highlight the complexity of molecular mechanisms underlying different types of migraine. 

Read more about the series' scope...

Have a look at what's already published and contribute to the series with your own research!

Article collections

Click here to see the article collections and thematic series that the journal has published in recent years.

Change to the journal’s peer review policy!

The Journal New Content Item (2)of Headache and Pain moves to transparent peer review (TPR).

Under TPR, the journal now publishes all reviewer reports along with the accepted articles under a Creative Commons Attribution License 4.0 but signing of reviewer reports will be optional.

The benefit of transparent peer review is that it increases transparency.  In addition, published reports can serve an educational purpose in helping facilitate training and research into peer review.

As a publisher we are firmly committed to the principles of, and move towards open research and science. This transition is reflective not only of our wider vision to support openness and transparency in peer review, a fundamental value at Springer Nature, but also ensuring that our mission and policies best align with the needs and requirements of the research community to support their development and engagement with the journals. Read more about the journal’s peer review policy here.

Editorial Board Spotlight

New Content ItemYonggang Wang MD is a physician-scientist at the Headache Department, Neurology Centre of the Beijing Tiantan Hospital and in Capital Medical University. His main research interests include pathophysiology of Headaches, neuroimage on headache and pharmacological management of headaches.

Q&A with Authors

Click here to see Q&As with the authors of the journal's most highly viewed articles!