From: Triptan use in elderly over 65 years and the risk of hospitalization for serious vascular events
Ā | Hazard ratio (95%CI) | Adjusted hazard ratio (95% CI) Exposed-unexposed | Adjusted hazard ratio (95% CI) Cumulative dose | Adjusted hazard ratio (95% CI) Time-varying |
---|---|---|---|---|
Exposure to triptans | ||||
Controls (non-exposed) | 1 | 1 | Ā | Ā |
Exposure to triptans (Triptan group) | 1.243 (1.043ā1.483) | 1.252 (1.050ā1.494) | Ā | Ā |
Exposure to triptans (time-varying) | ||||
Currently exposed at the time of event | 8.691 (5.186ā14.564) | - | - | 8.745 (5.214ā14.668) |
Not currently exposed at the time of event | 0.930 (0.760ā1.137) | Ā | Ā | 0.926 (0.757ā1.133 |
Cumulative dose (triptans) since index date (DDDs) | ||||
Controls (non-exposed) | 1 | - | 1 | - |
<ā12 | 1.861 (1.431ā2.420) | Ā | 1.852 (1.424ā2.410) | Ā |
12 | 1.172 (0.876ā1.566) | Ā | 1.173 (0.877ā1.569) | Ā |
>ā12 | 0.600 (0.383ā0.940) | Ā | 0.598 (0.382ā0.937) | Ā |
Charlsonās score (0) | 1 | Ā | Ā | Ā |
1ā2 | 0.949 (0.644ā1.399) | - | - | - |
3ā4 | 1.152 (0.674ā1.967) | Ā | Ā | Ā |
>ā5 | 1.337 (0.646ā2.767) | Ā | Ā | Ā |
Days of hospitalization (0) | 1 | Ā | Ā | - |
ā¤ā4 | 0.861 (0.539ā1.375) | - | Ā | Ā |
>ā5 | 0.852 (0.537ā1.351) | Ā | Ā | Ā |
Number of medical visits (0ā2) | 1 | - | - | - |
3ā4 | 1.154 (0.667ā1.996) | Ā | Ā | Ā |
5ā7 | 0.907 (0.537ā1.531) | Ā | Ā | Ā |
>ā7 | 1.223 (0.759ā1.971) | Ā | Ā | Ā |